The AGC is one of the first academic core facilities to optimize this exciting and powerful instrument, that is about the size of a large laser printer. About Over the past decade, the University of Michigan has become a leader in natural product sciences. Data Freeze 4, the most current Freeze, was released in July 2021 and contains data from 60,215 genotyped MGI participants. Each session will be 30-45 minutes, followed by a live Q&A. MGI participant ages range from 18 to above 89. Spatial Applications can help both research and clinical development . Please select one of the services and platform offered at the Advanced Genomics Core. Chief among these is "next-generation" sequencing (NGS), which has revolutionized research in virtually all biological fields in the past decade. EECS 409-001: Each semester MIDAS hosts weekly seminars featuring data science leaders from industry and academia. Nashville, TN. The authors also acknowledge the Michigan Genomics Initiative participants, Precision Health at the University of Michigan, and the University of Michigan Medical School Data Office for Clinical and Translational Research, the University of Michigan Medical School Central Biorepository, and the University of Michigan Advanced Genomics Core for . —. The Advanced Genomics Core The mission is to facilitate research in cutting-edge fields of genetics and genomics by implementing complex technologies. He observed that, after sleep deprivation, there was a significant increase in abundance of a type of RNA transcripts known to be present specifically in interneurons that express the neuropeptide somatostatin as well as the inhibitory neurotransmitter GABA. Library Prep and Next Generation Sequencing. Hosted by 10x Genomics and The University of Michigan Advanced Genomics Core. COVID-19 vaccinations, including boosters when eligible, are required for all University of Michigan students, faculty and staff across all campuses, including Michigan . CubeWorks was founded by pioneering researchers at the University of Michigan, and the company uses core technology stemming from 10+ years of ultra-low power VLSI circuit research that enables ultra-low power wireless sensors with unprecedented form factors and battery life. Initially adopted by the Medical School's Biomedical Research Core Facilities (BRCF) in Fall 2013, Agilent CrossLab iLab Operations Software is a core facility management system designed to support operations for a myriad of types and sizes of centralized labs and shared resource facilities. Our areas of expertise […] 28,251 (≈ 47%) of participants are male and 31,964 (≈ 53%) are female. Clinical Genetics training is offered through the 2 year Medical Genetics Residency Program or the Combined Pediatrics/Medical Genetics 4 year program . The Advanced Genomics Core mission is to facilitate research in cutting-edge fields of genetics and genomics by implementing complex technologies. Estimate. Primary Contact for Histology: Chelsea Decker. MGI participant ages range from 18 to above 89. Biointerfaces Institute (BI) offers a suite of instrumentation capabilities that include 3D Bioprinting, Material and Particle Characterization and Rheology. The UCSF BCMM is focused on human microbiome research, with a particular interest in accelerating discovery and translation in the fields of early life microbiome and therapeutic development. Illumina-ready Libraries for NGS. Statistical Population Genetics. Its goal is to use state-of-the-art instrumentation and innovative technical expertise in order to provide investigators with the highest quality genomic data from a comprehensive range of genomic services in a timely manner. Contributor(s) Lama VN, Braeuer RR, Walker N, Vittal R: Citation(s . The University of Michigan (U-M) Training Program in ELSI Research, funded by the National Institutes of Health, seeks to prepare the next generation of ELSI . RNA concentration and quality were determined and ribosomal depleted mRNA libraries were prepared by the University of Michigan Advanced Genomics Core. College of Literature, Science, and the Arts 235 people | 101 documents. For sorting of fibroblasts . Visit the Website / More Info. Fall term - 3 credits. The median age is 59 years, 62 for males and 57 for females (Figure 1). Experience and knowledge in fungal or microbial systems is desired. Imaging mass cytometry (IMC) IMC is a state-of-the-art technology available at the CyTOF core of the Rogel Cancer Center Immune Monitoring Shared Resources that allows simultaneous imaging of 40 parameters at 1 μm resolution. The Core occupies approximately 10,000 square feet of laboratory space in the North Campus Research Complex, with 22 highly-trained individuals on staff to help you. The University of Michigan Bru-seq Lab is a core facility that provides nascent RNA sequencing using four techniques: Bru-seq, BruChase-seq, BruUV-seq, and BruDRB-seq. Paper cited: Michki et al., 28,251 (≈ 47%) of participants are male and 31,964 (≈ 53%) are female. We are a full-service Core, and work closely with our investigators to meet their needs and make their research as successful as possible. Attendance required for completion of this course. The Advanced Genomics Core (AGC), part of the Biomedical Research Core Facilities within the Medical School Office of Research, provides high-quality, low-cost next generation sequencing analysis for research clients on a recharge basis. This work is supported by funding from the University of Michigan, including the MCubed program, Department of Cell and Developmental Biology's IDEA Awards in Stem Cell Biology, and the MTRAC program. 8 Advanced Genomics Core, Biomedical Research Core Facility, University of Michigan, Ann Arbor, Michigan, USA. We serve researchers from the University of Michigan, and other institutions in the United States and around the world. Hours. College of Literature, Science & Arts 138 people | 76 documents. Director of the UNC Microbiome Core Associate Professor of Medicine in the School of Medicine at UNC Chapel Hill Speaker Profile: M. Andrea Azcarate-Peril, Ph. Michigan Medicine, formerly the University of Michigan Health System (UMHS), is the wholly owned academic medical center of the University of Michigan, in Ann Arbor.It includes the U-M Medical School, with its faculty group practice and many research laboratories; the U-M hospitals and health centers, which include the University of Michigan Hospital, C.S. Bachelor's Degree. The Center is developing multiple collaborative labs (CoLabs), technology hubs that facilitate microbiome research projects. In conjunction with BRCF's Advanced Genomics Core and NanoString's upcoming schedule of events, NanoString is also offering a grant program to quantitatively map the whole transcriptome to user-defined regions of FFPE/fresh-frozen tissue using the GeoMx Digital Spatial Profiler. Biostatistics 830. Join us for an engaging week of presentations from a diverse group of scientists and hear about the latest advancements from 10x Genomics in single cell and spatial genomics. The University of Michigan Biomedical Research Core Facilities (BRCF) Advanced Genomics Core (AGC) provides high-quality, low-cost advanced genomic analysis for research clients on a recharge basis. Aug 2015 - Nov 20183 years 4 months. During the remainder of the week, the lab will prepare a large batch of experimental samples, which will be submitted for high throughput sequencing at the U-M Advanced Genomics Core. The University of Michigan Rogel Cancer Center supports and maintains a state-of-the-art histology and immunohistochemistry laboratory using automated instruments. The University of Michigan Bru-seq Lab is a core facility that provides nascent RNA sequencing services for samples prepared using the Bru-seq suite of techniques. The School currently has 3,040 faculty members teaching 785 medical students, 685 graduate students, 540 postdoctoral fellows, and over 1,300 interns and residents, as well as other groups of . The generated datasets will require . University of Michigan Researchers and External Researchers Visit Core Website Core Summary The University of Michigan Biomedical Research Core Facilities (BRCF) Advanced Genomics Core (AGC) provides high-quality, low-cost advanced genomic analysis for research clients on a recharge basis. College of LSA Dean's Office 49 people | 2 documents. One NovaSeq run can generate as much as 4TB of raw data. The team used two U-M core facilities, the Flow Cytometry Core and the Advanced Genomics Core. 9 Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA. Presented by 10x Genomics and University of Michigan Advanced Genomics Core Deep insights into tumor biology, developmental biology, and other biological processes and disease states require a comprehensive view of gene expression patterns and their corresponding epigenetic regulation at single cell resolution. Our Process MSRB-1 4504. Mouse tumors were treated with Vehicle or HH inhibitor for 14 days after formation of tumors. Product Enablement Scientist; April 28th: Introduction to Single Cell Spatial-Omics - CosMx Spatial Molecular Imager On the cutting-edge of research at U-M is the Advanced Genomics Core's Illumina NovaSeq 6000 sequencing platform. Both training programs are ACGME-accredited and are based in the Department of Pediatrics. Dr. Azcarate-Peril currently conducts research in modulation of the host-associated microbiota by prebiotics and probiotics. The Advanced Technology Genomics Core (ATGC) is the primary, "one-stop" genomics core facility for researchers at MD Anderson Cancer Center. The Advanced Genomics Core (AGC), part of the Biomedical Research Core Facilities within the Medical School Office of Research, provides high-quality, low-cost next generation sequencing analysis for research clients on a recharge basis. The single cell RNA-seq libraries were prepared at the University of Michigan Advanced Genomics Core using the 10X Genomics Chromium Next GEM Single Cell 3′ Kit v3.1 (part number 1000268) following the manufacturer's protocol. Libraries were sequenced using 150 paired end NovaSeq 6000 (Illumina). Required Course for DS Certificate and DS Masters: EECS 409. Each program utilizes the combined clinical genetics services, basic science research and education . mweivoda@umich.edu Research Interests: The mechanisms by which multi-nucleated osteoclasts stimulate osteoblastic bone formation in order to identify therapeutic targets to promote bone formation in aging and cancer-induced bone disease. Mott Children's Hospital, Von . In addition, users will have access to our exclusive pipeline to perform further data analysis. 3. The AGC occupies approximately 10,000 square feet of laboratory space. Ph.D. - Faculty Director Professor of Pathology Professor of Human Genetics 2065 BSRB 109 Zina Pitcher Place Ann Arbor, MI 48109-2200 wilsonte@umich.edu 734-764-2212 Articles ↓ Web Sites ↓ Administrative Contact Carrie Callahan, carcalla@umich.edu Areas of Interest 1) Mechanistic studies of DNA double-strand break repair. University of Michigan Advanced Genomics Core Cost Estimator. Department of Computational Medicine and Bioinformatics Nationally respected for our interdisciplinary research and training programs, we strive to create novel informatics- and computationally-based methods, tools, and algorithms for basic biomedical, translational, and clinical research. • Manage the daily operations of Vanderbilt's Genomics Core facility, providing advanced genomic . BRCF Advanced Genomics Core (AGC) provides high-quality, low-cost advanced genomic analysis on a recharge basis. Research has been returning to full capacity over several phases, with restrictions lifted in each subsequent phase, as informed by outcomes and public health guidelines. This work is supported by funding from the University of Michigan, including the MCubed program, Department of Cell and Developmental Biology's IDEA Awards in Stem Cell Biology, and the MTRAC program. Coordination with the Advanced Genomics Core for submission of samples and communication with the core regarding anticipated sample flow to ensure adequate supplies; . provides high-quality, low-cost advanced genomic analysis for research clients on a recharge basis. The Department of Veterans Affairs, VA Ann Arbor Medical Center VISN 10,2215 Fuller Road, Ann Arbor MI 48105, in accordance with FAR 13.106-1(b), intends to request quota AJ11--Advanced Genomics Core UofM - Dr. Mody The Bachelors of Science in Engineering (BSE) degree in Mechanical Engineering (ME) at the University of Michigan requires students to complete 128 credit hours of courses in various categories, which include: College of Engineering (CoE) core, intellectual breadth, ME program specific courses, and general electives. Thom Saunders, PhD 734-647-2910 tsaunder@umich.edu 1150 W. Medical Center Dr. Ann Arbor, MI 48109. Presented By: NanoString and the BRCF Advanced Genomics Core Spatial genomics and transcriptomics is a rapidly evolving area of research that enables correlation of the expression of tens of thousands of genes and hundreds of proteins with morphological location in a tissue. Primary Contact for IHC: Kathy Toy. developed by central campus, while at the same time recognizing the unique needs and circumstances of research at the Medical School. Service Detail. Delorme then collaborated with U-M Advanced Genomics core for the RNA sequencing. Biostatistics 866. Chief among these is "next-generation" sequencing (NGS), which has revolutionized research in virtually all biological fields in the past decade. Services. Olivia Koues, PhD advanced-genomics@umich.edu BRCF Bioinformatics Core assists with the experimental design, workflow development, and analysis of next-generation sequencing data. Seminars are held Mondays from 4-5pm. We provide centralized expertise in advanced methods that enables all researchers to effectively exploit them for making scientific discoveries. The Advanced Genomics Core is continuously changing to adapt to the latest technologies. Cognitive Science and Art and Design 1 person. Sarah Spanninga, PhD. Program Overview. He is Director of the Single Cell Spatial Analysis Program; Associate Director for Shared Resource for the University of Michigan Comprehensive Rogel Cancer Center; Directs an NIH-funded Program Project on Prostate Cancer Bone Metastasis; and Co-Director of the Single Cell Analysis Core. The Advanced Genomics Core (AGC), part of the Biomedical Research Core Facilities within the Medical School Office of Research, provides high-quality, low-cost next generation sequencing analysis for research clients on a recharge basis. The last interest led to Dr. Wilson becoming co-PI of the Michigan Single-Cell Spatial Analysis Program as head of the core services support team, in conjunction with his larger role as Faculty Director of the Advanced Genomics Core. Figure 1. One NovaSeq run can generate as much as 4TB of raw data. 734-615-3758. bi-equipment@umich.edu. He observed that, after sleep deprivation, there was a significant increase in abundance of a type of RNA transcripts known to be present specifically in interneurons that express the neuropeptide somatostatin as well as the inhibitory neurotransmitter GABA. Dramatic advances in genetics and genomics promise to enhance medicine and public health, but they also pose important ethical, legal, and social implications (ELSI). We also thank Dr. Tom Wilson for discussions of the data. The total number of cells recovered was 11,118. What is MiCORES? The Advanced Genomics Core mission is to facilitate research in cutting-edge fields of genetics and genomics by implementing complex technologies. Office of Research, University of Michigan Medical School C560 MSRB II, 1150 W. Medical Center Dr. Ann Arbor, MI 48109-0674 Phone: 734-647-4776 Fax: 734-936-2622 Email: brcf-umms@umich.edu Single-Cell Processing. GeoMx Project Requirements: University of Michigan Advanced Genomics Core; April 14th: GeoMx Data Analysis Workshop. Evan T. Keller, DVM, PhD is a Professor of Urology and Pathology, School of Medicine, University of Michigan. The BRCF Advanced Genomics Core and Illumina team invites you to join a webinar March 10th from 1:00 - 2:00 PM EDT for an introduction to RNA-Seq, with insight into library preparation, analysis solutions, and potential applications. Course Description: HG541, Molecular Genetics, is a course that explores how the information content of the DNA genome is (i) organized, propagated, and altered, and (ii) functionally expressed by regulated transcription into RNA - the core molecular properties and processes of genetic systems that underlie all further investigations of organismal, clinical, and . The AGC is one of the first academic core facilities to optimize this exciting and powerful instrument, that is about the size of a large laser printer. The ideal candidate will have skills in one or more of the following areas: bioinformatics using second or third generation sequencing data, comparative genomics, advanced fluorescence or electron microscopy, molecular biology such as cloning, and working with living cultures. The authors acknowledge the Cardiovascular Health Improvement Project, Michigan Genomics Initiative, Precision Health at the University of Michigan, and the University of Michigan Medical School Central Biorepository, and the University of Michigan Advanced Genomics Core for providing data and biospecimen storage, management, processing, and . We thank the University of Michigan Advanced Genomics Core for performing the targeted capture sequencing and 10X linked-read sequencing. Fall term - 3 credits. Core competencies include both targeted assays for many analyte classes as well as untargeted assays to evaluate the entire metabolome in biofluids and tissues, measurement of flux through various pathways using 13C-isotopomer analyses, and structural identification of isolated unknowns and potential biomarkers. IMC uses antibodies conjugated to heavy metals to detect markers in a manner analogous to immuno-histochemistry or immunofluorescence microscopy. GeoMx DSP Data Analysis Software Overview: Prajan Divakar, PhD, Sr. Vanderbilt University Medical Center. Data Freeze 4, the most current Freeze, was released in July 2021 and contains data from 60,215 genotyped MGI participants. Medical School COVID-19 Research Operations. The AGC is one of the first academic core facilities to optimize this exciting and powerful instrument, that is about the size of a large laser printer. The University of Michigan Skin Biology and Diseases Resource-based Center (UM-SBDRC) will accelerate the science and innovation of the Center's members and the broader community of cutaneous researchers by supporting innovative basic research in cutaneous biology and facilitating its translation to clinical practice. Throughout, Dr. Wilson has a strong interest in bioinformatics and computational sciences and his research . Delorme then collaborated with U-M Advanced Genomics core for the RNA sequencing. One NovaSeq run can generate as much as 4TB of raw data. Paper cited: Michki et al., On the cutting-edge of research at U-M is the Advanced Genomics Core's Illumina NovaSeq 6000 sequencing platform. On the cutting-edge of research at U-M is the Advanced Genomics Core's Illumina NovaSeq 6000 sequencing platform. This service is all-inclusive, starting with cells and ending with basic data analysis. Users can request services for these four assays: BruUV-seq . College of Education, Health, and Human Services (Dearborn) 4 people. The LSI's Natural Products Discovery Core has developed a 45,000-sample (and growing) library of natural product extracts derived from a unique collection of diverse marine and terrestrial actinomycetes, fungi and cyanobacteria. Olivia Koues, PhD advanced-genomics@umich.edu BRCF Transgenic Animal Model Core provide access to transgenic animal technology in an efficient, effective manner. Bioinformatics Core 734-998-9249 bioinformatics@umich.edu Biostatistics 665. Once collected, the nascent Bru-labeled RNAs were sequenced at the University of Michigan Advanced Genomics Core, and Bedi used a custom-designed computational analysis pipeline to analyze the . Course Description: HG541, Molecular Genetics, is a course that explores how the information content of the DNA genome is (i) organized, propagated, and altered, and (ii) functionally expressed by regulated transcription into RNA - the core molecular properties and processes of genetic systems that underlie all further investigations of organismal, clinical, and . Course Title. The University of Michigan Medical School began in the year 1850 with five faculty members, 90 students, and five physicians seeking additional training. The median age is 59 years, 62 for males and 57 for females (Figure 1). Leadership Olivia I. Koues, Ph.D. - Managing Director Thomas E. Wilson, M.D. Lab Number: (734) 647-3261. Figure 1. Michigan Research Cores explores the many services, equipment, and instrumentation that the various University of Michigan core facilities have to offer. View the seminar schedule. The team used two U-M core facilities, the Flow Cytometry Core and the Advanced Genomics Core. Services. D. is Associate Professor of Medicine in the School of Medicine at UNC Chapel Hill. Advanced Topics in Biostatistics (if genomics focused) 3-4. BRCF Advanced Genomics Core (AGC) provides high-quality, low-cost advanced genomic analysis on a recharge basis. They hope that the Advanced Genomics Core will remain operational and will be able to perform sequencing of their samples.
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